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Vitamin B12
Vitamin B12
Vitamin B12
Vitamin B12
Vitamin B12

Vitamin B12

This essential vitamin is necessary for energy production, mood regulation, cognitive support, metabolic functions, digestion and more.
  • Energy Boost
  • Cognitive Focus and Memory
  • Mood Enhancement and Anti-Anxiety
  • Metabolism Optimizer
  • Heart Health and Blood Pressure
  • Cell Production and Repair
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A Powerful Boost of Vitamin B12

  • Energy Boost

    B12 plays an essential role in helping the body convert nutrients from food into fuel.11 It’s needed to produce red blood cells which deliver fresh oxygen throughout the body.12 B12 is a natural energy booster, helping you to feel vital and ready for anything.

  • Cognitive Focus and Memory

    Vitamin B12 plays a role in nerve health and neurotransmitter signaling.1 Studies suggest13,14 that it is needed for concentration and cognitive processes. It may help prevent neurodegenerative diseases, including dementia15 and Alzheimer’s disease.16

  • Mood Enhancement and Anti-Anxiety

    The energy boost from B12 alone can go a long way in helping with mood.17 Research has also shown18 that B12 is necessary for producing the SAMe compound, which is crucial for neurological function, stress response and mood regulation.

  • Metabolism Optimizer

    B12 helps you to burn nutrients efficiently,11 which is not only important for energy and weight management, but also immune function, cell production and a whole host of other things.

  • Heart Health and Blood Pressure

    Research suggests19 that B12 may fight cardiovascular disease by lowering levels of homocysteine, an amino acid in the blood that in high concentrations has been linked to stroke and heart attack.20

  • Cell Production and Repair

    A big part of metabolism is making and repairing the cells in your body. B12 is important for DNA synthesis and repair,18 and to assist in the production of the building blocks such as amino acids and lipids needed for cell growth.

Health Benefits
Health Benefits

Fast, Easy and Vegan Way to Boost B12 and Reverse Deficiency

2500 Micrograms of Methylcobalamin B12 per Dissolvable Tablet

There’s nothing that says “a vampire sucked my blood and all I got was a lousy t-shirt” like a Vitamin B12 deficiency. Chronic fatigue and brain fog are among the most common complaints. This essential vitamin is necessary for energy production, mood regulation, cognitive support, metabolic functions, digestion and more.1,2

Lots of people are low in B12. Because almost no plants contain a high dose of bioavailable Vitamin B12 3, vegans and many vegetarians need to take a supplement to get their fill.4 People over the age of 65 have been found to be at increased risk of B12 deficiency.5 Also folks with impaired digestion easily become deficient because they lack the digestive fire needed to absorb B12. This is especially true of people with IBS, Crohn’s disease 6 and those taking stomach acid-lowering medication.7 The blood sugar regulating drug metformin has also been found to lead to low B12 levels.8

Nested Naturals B12 is an easy to chew tablet, no glass of water needed. We use the methylcobalamin form of B12 because some studies suggest that it offers better bioavailability than the cheaper cyanocobalamin form.9

The ingredients inside Vitamin B12

  • B12 for an Instant Boost

    Taking B12 under your tongue sends the vitamin directly into your bloodstream. This is awesome for people whose stomachs lack the intrinsic factor needed to absorb B12 through the digestive tract.10

  • Most Bioavailable Form of Vitamin B12

    We use the methylcobalamin form of B12. Studies suggest 9 it may be easier for the body to use than the cheaper cyanocobalamin form which the body must convert. Only the best for our friends and customers!

  • Convenient, Easy Dissolve Tablets

    Other B12 supplements come in liquid form which isn’t very convenient for on-the-go use. Our tablets that are simple to dissolve and chew are easy like Sunday morning.

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Supplement Facts

Serving Size: 1 Tablet
Servings Per Container: 90
Amount per serving % Daily Value
Vitamin B12 (Methylcobalamin) 2,500 mcg 104,167%
Other Ingredients: Xylitol, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate
Allergens: This product contains no GMO, soy, dairy, egg, fish, shellfish, peanuts, tree nuts yeast or barley. Contains traces of wheat and corn. Proudly vegan, third-party tested, and manufactured in a NSF certified cGMP facility in the USA using worldwide ingredients.
Storage Instructions: Store in a cool, dry place. Avoid excessive heat. Do not use if safety seal is broken.
  • Herb Identification We Test For
    Herb Identification

    Chromatography

    We confirm the identity of each herb by using a highly specific and accurate test method based on chromatographic fingerprinting.

  • Microbial Testing We Test For
    Microbial Counts

    Pathogens

    The raw ingredients and final supplement are tested for concerning pathogens.

  • Heavy Metals Testing We Test For
    Heavy Metals

    Not the music

    The raw ingredients and final supplement are tested for arsenic, cadmium, mercury, and lead.

  • Amount Testing We Test For
    Potency

    Third Party

    We work with third party labs to test the amount of vitamins, minerals, and specific active ingredients.

Discover what our customers say about Vitamin B12

Reviews ()

Resources

The science behind the claims

  • Vitamin B12, folic acid, and the nervous system
    Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurology. 2006;5(11):949-960.
  • Vitamin B12 in health and disease
    O'Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299-316.
  • Vitamin B12 sources and bioavailability
    Watanabe F. Vitamin B12 sources and bioavailability. Exp Biol Med. 2007;232(10):1266-1274.
  • The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: A review of literature
    Pawlak R, Lester SE, Babatunde T. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: A review of literature. Eur J Clin Nutr. 2016;70(7):866
  • Vitamin B12 (cobalamin) deficiency in elderly patients
    Andres E, Loukili NH, Noel E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. Can Med Assoc J. 2004;171(3):251-259.
  • Increased levels of homocysteine in patients with crohn's disease are related to folate levels
    Chowers Y, Sela B, Holland R, Fidder H, Simoni FB, Bar-Meir S. Increased levels of homocysteine in patients with crohn's disease are related to folate levels. Am J Gastroenterol. 2000;95(12):3498-3502.
  • Omeprazole and vitamin B12 deficiency
    Bradford GS, Taylor CT. Omeprazole and vitamin B12 deficiency. Ann Pharmacother. 1999;33(5):641-643.
  • Risk factors of vitamin B12 deficiency in patients receiving metformin
    Ting RZ, Szeto CC, Chan MH, Ma KK, Chow KM. Risk factors of vitamin B12 deficiency in patients receiving metformin. Arch Intern Med. 2006;166(18):1975-1979.
  • Comparative bioavailability and utilization of particular forms of B12 supplements with potential to mitigate B12-related genetic polymorphisms
    Paul C, Brady DM. Comparative bioavailability and utilization of particular forms of B12 supplements with potential to mitigate B12-related genetic polymorphisms. Integrative Medicine. 2017;16(1):42.
  • Vitamin B12 absorption: Mammalian physiology and acquired and inherited disorders
    Kozyraki R, Cases O. Vitamin B12 absorption: Mammalian physiology and acquired and inherited disorders. Biochimie. 2012;95(5):1002.
  • Mitochondrial function and toxicity: Role of B vitamins on the one-carbon transfer pathways
    Depeint F, Bruce WR, Shangari N, Mehta R, O’Brien PJ.Mitochondrial function and toxicity: Role of B vitamins on the one-carbon transfer pathways. Chem Biol Interact. 2006;163(1):113-132
  • New insights into erythropoiesis: The roles of folate, vitamin B12, and iron
    Koury MJ, Ponka P. New insights into erythropoiesis: The roles of folate, vitamin B12, and iron. Annu Rev Nutr. 2004;24(1):105-131.
  • Assessment of brain cognitive functions in patients with vitamin B12 deficiency using resting state functional MRI: A longitudinal study
    Gupta L, Gupta RK, Gupta PK, Malhotra HS, Saha I, Garg RK.Assessment of brain cognitive functions in patients with vitamin B12 deficiency using resting state functional MRI: A longitudinal study. Magn Reson Imaging. 2015;34(2):191
  • Cognitive impairment and vitamin B12: A review
    Moore E, Mander A, Ames D, Carne R, Sanders K, Watters D.Cognitive impairment and vitamin B12: A review. Int Psychogeriatr. 2012;24(4):541-556.
  • Metabolic vitamin B12 deficiency: A missed opportunity to prevent dementia and stroke
    Spence JD. Metabolic vitamin B12 deficiency: A missed opportunity to prevent dementia and stroke. Nutrition research (New York, N.Y.). 2016;36(2):109-116
  • Folate, vitamin B12, and serum total homocysteine levels in confirmed alzheimer disease
    Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM.Folate, vitamin B12, and serum total homocysteine levels in confirmed alzheimer disease. Arch Neurol. 1998;55(11):1449-1455.
  • Treatment of depression: Time to consider folic acid and vitamin B12
    Coppen A, Bolander-Gouaille C. Treatment of depression: Time to consider folic acid and vitamin B12. Journal of Psychopharmacology. 2005;19(1):59-65
  • Folate, vitamin B12 and vitamin B6 and one carbon metabolism
    Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging. 2002;6(1):39-42.
  • The role of Homocysteine‐Lowering B‐Vitamins in the primary prevention of cardiovascular disease
    Debreceni B, Debreceni L. The role of Homocysteine‐Lowering B‐Vitamins in the primary prevention of cardiovascular disease. Cardiovascular Therapeutics. 2014;32(3):130-138.
  • Role of homocysteine in the development of cardiovascular disease
    Ganguly P, Alam SF.Role of homocysteine in the development of cardiovascular disease. Nutrition journal. 2015;14(1):6.
  • Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline
    Institute of Medicine, Food and Nutrition Board, Planning Committee on Dietary Reference Intakes Research Synthesis.Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. In: ; 2007:35-48.
  • Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults
    Rajan S, Wallace JI, Brodkin KI, Beresford SA, Allen RH, Stabler SP.Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults. J Am Geriatr Soc. 2002;50(11):1789-1795.
  • High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): Relevance to genetic disease and polymorphisms
    Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): Relevance to genetic disease and polymorphisms. Am J Clin Nutr. 2002;75(4):616.
  • Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy
    Watanabe T, Kaji R, Oka N, Bara W, Kimura J. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci. 1994;122(2):140-143.