Cranberry-powered support for a healthy urinary tract

8 Answered Questions
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Cleanse and Maintain a Healthy Urinary Tract

Concentrated D-Mannose and Organic Cranberry Extract for a Super-powered Supplement

Cranberries aren’t just great for Thanksgiving dinner. If you struggle with urinary health you’ve probably been told to drink lots of cranberry juice. This is because cranberries include a nutrient called D-Mannose which research is showing might help maintain a healthy, clean urinary tract to support the body’s defenses against occasional UTI’s .1,2

Most UTIs are caused when E. coli, a very common bacteria, finds its way into the urinary tract, sticks to the lining and multiplies.3 We like to think of D-Mannose and E. coli as star-crossed lovers, like Romeo and Juliet. Once they meet, the E. coli is so attracted to the D-Mannose, it lets go of the urinary tract lining to embrace its new paramour and together they make a quick (if not poetic) exit through your urine.1,2,4 Our formulation is designed to help promote your urinary tract health and normal cleansing of the urinary tract lining.

Cranberries are superfoods. In addition to D-Mannose, they also are loaded with other beneficial compounds.5 But cranberries are extremely tart and hard to stomach without adding piles of sugar—just check out the label of your favorite cranberry juice. The problem with added sugar is that many people aim to eliminate, or reduce, added sugars from their diet. D-mannose, on the other hand, is a simple sugar, but is not fully metabolized by the body and is excreted in the urine so it is less likely to spike your blood sugar – unlike the added sugar in cranberry juice!

Nested Naturals D-Mannose Plus gives you the benefits of an impossibly huge serving of cranberries in one potent capsule. It’s much more concentrated than cranberry juice and there’s no added sugar. We include both D-Mannose naturally sourced from non-GMO corn to aid urinary health and extract of organic cranberries for a nutrient boost. D-Mannose Plus is formulated to support your urinary tract health and help your immune system clear occasional UTIs before they take hold. As usual, if a UTI develops and becomes problematic, please see your healthcare provider as soon as possible.

D-Mannose Plus Cranberry Without Added Sugar

Maintain Urinary Tract Health

Prevention is always the best medicine. D-Mannose can help bind to stray E. coli to cleanse and maintain the health of the urinary tract.6 The organic cranberry extract in our formula gives extra support to the immune system.7

Binds to E. Coli, But Leaves Good Bacteria Alone

D-Mannose only binds to E. coli and leaves all your good bacteria alone.8 And it takes a kinder, gentler approach; it doesn’t kill anything. Rather, it flows through your kidneys and urinary tract, sticking to some E. coli along the way and together they are excreted. Research8, 9 has also suggested that both cranberry and D-mannose may support beneficial bacteria in your gut.

The Active Ingredients Inside D-Mannose

A Blend of Concentrated D-Mannose and Organic Cranberry Extract

Supplement Facts
Serving Size: 1 Vegan Capsule Servings Per Container: 60
Amount per Serving % DV
500 mg
(Extract) (Vaccinium Macrocarpon L.)
200 mg

† Daily Value (DV) not established

Other Ingredients: Vegetable Cellulose (capsule), Rice Flour, Magnesium Stearate

This product contains no wheat, gluten, GMO, soy, dairy, egg, fish, shellfish, nuts, tree nuts, yeast, barley or added sugar. Proudly vegan, third-party tested and manufactured in a NSF certified cGMP facility in the USA using worldwide ingredients.

Store in a cool, dry place. Avoid excessive heat. Do not use if safety seal is broken.

Highly Concentrated

One capsule of Nested Naturals D-Mannose Plus gives you 500 mg of D-Mannose sourced from non-GMO corn and 200 mg of organic cranberry extract. It’s much more concentrated than cranberry juice and there’s no added sugar. Our formulation is designed to give your body the support it needs to prevent occasional UTI's.

Added Cranberries for Immune Support

Cranberries are rich in nutrients, which have been shown to support healthy immune function.5,10 Many D-Mannose supplements on the market, leave the cranberry out of their formulas. We include organic cranberry extract in our blend so that you get the full benefit of this superfood.7

Naturally Sourced, Non-GMO & Food-Based

We are relentless about sourcing the best, most naturally sourced, most ethically produced ingredients available. The active ingredients in Nested Naturals D-Mannose Plus come from organic cranberries and non-GMO corn.

Pure and Made with Love

We make D-Mannose Plus with love. We believe that nutritional supplements should be like mother’s milk: naturally sourced, full of good stuff, but nothing extra. We don’t add any sugar.

Your Questions, Our Answers

See the most popular questions asked about D-Mannose.

How should I use D-Mannose if I feel a UTI coming on?

D-Mannose is best used as a preventative measure rather than a treatment for a full-blown infection. When you maintain a healthy, clean urinary tract, your immune system has a fighting chance of clearing out any stray E. coli before they colonize your bladder and urinary tract.

If your symptoms don’t improve after a day or two on D-Mannose, you’ll need to seek medical attention and get antibiotics. Roughly 10% of UTIs are caused by a bacteria different than E. coli and D-mannose will be of no help in those cases.

It’s important to know that sometimes antibiotics are necessary to treat UTIs. Bacteria can multiply quickly in the urinary tract and an infection is not only uncomfortable, but it can become much more serious.

How can I use D-mannose to help me get off the cycle of antibiotics and UTIs?

Antibiotics are sometimes a necessity in treating infections, but they kill off good as well as bad bacteria in your body. If you are caught in a cycle of chronic UTIs and antibiotic use, you might try rebooting your system by taking two supplements: D-Mannose and probiotics as well as any medications prescribed by your healthcare provider . The intention is for the D-Mannose to help cleanse and maintain a healthy urinary tract while the probiotics help to rebuild the good bacteria in your gut. The D-Mannose also might serve as a prebiotic and promote the growth of good bacteria.

Rebooting takes time; you’ll need to plan to supplement with D-Mannose for six months.

Important note: If a UTI takes hold, it’s important to seek medical attention. You may need antibiotics to clear the infection.

How do I know if the D-Mannose is working?

Any urinary discomfort will improve within a day or two. If your symptoms either stay the same or get worse, please consult with a doctor. You may need antibiotics to clear the infection.

What is vegetable cellulose & what is it doing in Nested Naturals D-Mannose?

We use vegetable cellulose to make our gel-caps. We’re proud to say that our capsules are vegan and don’t include any animal parts.

What is magnesium stearate and what is it doing in Nested Naturals D-Mannose?

We use tiny amounts of magnesium stearate as a flow agent during the manufacturing process. It ensures that the supplement ingredients fill the capsule consistently and properly.

What is rice flour doing in Nested Naturals D-Mannose?

Rice flour helps flow the supplement ingredients into the capsule. Minuscule amounts are used during the manufacturing process. You’ll find it listed under “Other Ingredients” on our label because we believe that you deserve to know everything that goes into our supplements and your body.

Is the Nested Naturals D-Mannose sugar-free?

Chemically speaking, D-Mannose is a sugar, so we can’t say that it the supplement is sugar-free. However, D-Mannose affects the body differently than sucrose and doesn’t spike blood sugar or tax the immune system. We don’t add any sugar to flavor the capsules. We believe that nutritional supplements should be like mother’s milk: naturally sourced, full of good stuff, but nothing extra.

Customer Reviews

Discover what real customers say about D-Mannose.

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Beverly K Verified Buyer 19/02/19
I have purchased D-Mannose/Cranberry in the past from another source. Those capsules had an odd odor/taste to them. That is not the case with the "Nested" capsules. These are much easier to take. I take 2 capsules per day, as my physician recommended 1000mg of D-Mannose.
Kathy R Verified Buyer 21/01/19
The D-Mannose is working great for me.Had a physical this past week and my doctor was impressed with my results.I have already ordered more.Thanks so much.I know I could find this elsewhere, but your product is definitely cheaper than my local health food store.
Patrica B Verified Buyer 27/03/17
Urologist has me on DMannose. Will be using yours soon
Read reviews from our lovely Amazon.com customers


The science behind all of our claims

  • 1. Kranjčec B, Papeš D, Altarac S.D-mannose powder for prophylaxis of recurrent urinary tract infections in women: A randomized clinical trial. World J Urol. 2014;32(1):79-84.
  • 2. Mathison BD, Kimble LL, Kaspar KL, Khoo C, Chew BP. Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: A randomized controlled trial. Nutrition research (New York, N.Y.). 2014;34(5):420-427.
  • 3. SHARON N, OFEK I, MIRELMAN D. Adherence of escherichia coli to human mucosal cells mediated by mannose receptors. Nature. 1977;265(5595):623-625.
  • 4. Zafriri D, Ofek I, Adar R, Pocino M, Sharon N.Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated escherichia coli to eucaryotic cells. Antimicrob Agents Chemother. 1989;33(1):92-98.
  • 5. Vattem DA, Ghaedian R, Shetty K. Enhancing health benefits of berries through phenolic antioxidant enrichment: Focus on cranberry. Asia Pac J Clin Nutr. 2005;14(2):120.