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  • vegan
  • thirdpartytested
  • madewithlove
  • gmpcertified
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D-Mannose

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Most UTIs are caused when E. coli, a very common bacteria, finds its way into the urinary tract, sticks to the lining and multiplies. D-Mannose helps at eliminate E. coli before they take hold.
  • Supportive Supplement to Maintain Urinary Tract Health
  • Binds to E. Coli in the Urinary Tract
  • vegan
  • thirdpartytested
  • gmpcertified
  • gmofree
  • madewithlove
$15.95 In Stock
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    D-Mannose Plus Cranberry Without Added Sugar

  • Supportive Supplement to Maintain Urinary Tract Health

    Prevention is always the best medicine. Our gentle, naturally sourced pill containing 500 mg of D-Mannose along with 200 mg of cranberry extract can help support a healthy, clean urinary tract. The organic cranberry extract in our formula gives extra support to the immune system.6,7

  • Binds to E. Coli in the Urinary Tract

    D-Mannose has been shown to help maintain a healthy urinary tract by attaching to stray bacteria and providing a free ride out of the body through the urine. Our D-Mannose can help to bind to stray E. coli to cleanse the urinary tract, supporting your bladder health.1,2 In addition, both cranberry and D-mannose may help to promote beneficial bacteria in your gut.8, 9

Health Benefits
Health Benefits

Support a Healthy Urinary Tract

D-Mannose and Organic Cranberry Extract for Urinary Support

Cranberries aren’t just great for Thanksgiving dinner. If you struggle with the occasional UTI you have probably been told to drink lots of cranberry juice. This is because cranberries include a nutrient called D-Mannose which helps to maintain a healthy, clean urinary tract to support the body's defenses against occasional UTI's.1,2

Most UTIs are caused when E. coli, a very common bacteria, finds its way into the urinary tract, sticks to the lining and multiplies.3 D-Mannose may be beneficial at promoting the body’s ability to clear stray E. coli before they have a chance to take hold, helping to maintain a healthy urinary tract.

D-Mannose occurs naturally in both cranberries and corn and has some supportive properties when it comes to E. coli. We like to think of D-Mannose and E. coli as star-crossed lovers, like Romeo and Juliet. Once they meet, the E. coli is so attracted to the D-Mannose, it lets go of the urinary tract lining to embrace its new paramour and together they make a quick (if not poetic) exit through your urine.1,2,4

Cranberries are superfoods. In addition to including the D-Mannose compound, they also are loaded with other beneficial compounds.But cranberries are extremely tart and hard to stomach without adding piles of sugar—just check out the label of your favorite cranberry juice. D-Mannose, on the other hand, is not fully metabolized by the body and is excreted in the urine so it is less likely to spike your blood sugar - unlike the added sugar in cranberry juice! We use cranberry extract, as it’s much more concentrated than cranberry juice and powder.

Nested Naturals D-Mannose Plus gives you the benefits of an impossibly huge serving of cranberries in one capsule. It’s much more concentrated than cranberry juice and there’s no added sugar. We include both D-Mannose naturally sourced from non-GMO corn support the urinary tract and extract of cranberries for an added boost. D-Mannose Plus is formulated to support a healthy urinary tract, which can deter UTIs before they take hold. If a UTI develops and becomes problematic, please see your healthcare provider as soon as possible.

The ingredients inside D-Mannose

  • Highly Concentrated

    One capsule of Nested Naturals D-Mannose Plus gives you 500 mg of D-Mannose sourced from non-GMO corn and 200 mg of organic cranberry extract. It’s much more concentrated than cranberry juice and there’s no added sugar. Our formulation is designed to give your body the support it needs to prevent occasional UTI's.

  • Added Cranberries for Immune Support

    Cranberries are rich in nutrients, which have been shown to support healthy immune function.5,10 Many D-Mannose supplements on the market, leave the cranberry out of their formulas. We include organic cranberry extract in our blend so that you get the full benefit of this superfood.7

  • Naturally Sourced, Non-GMO & Food-Based

    We are relentless about sourcing the best, most naturally sourced, most ethically produced ingredients available. The active ingredients in Nested Naturals D-Mannose Plus come from organic cranberries and non-GMO corn.

  • Pure and Made with Love

    We make D-Mannose Plus with love. We believe that nutritional supplements should be like mother’s milk: naturally sourced, full of good stuff, but nothing extra. We don’t add any sugar.

Supplement Facts

Serving Size: 1 Vegan Capsule
Servings Per Container: 60
Amount per serving % Daily Value
D-Mannose 500 mg
Cranberry Extract (Vaccinium Macrocarpon L.) 200 mg
† Daily Value not established.

Testing Process

Each batch goes through 4 stages of testing

  • Herb Identification We Test For
    Herb Identification

    Chromatography

    We confirm the identity of each herb by using a highly specific and accurate test method based on chromatographic fingerprinting.

  • Microbial Testing We Test For
    Microbial Counts

    Pathogens

    The raw ingredients and final supplement are tested for concerning pathogens.

  • Heavy Metals Testing We Test For
    Heavy Metals

    Not the music

    The raw ingredients and final supplement are tested for arsenic, cadmium, mercury, and lead.

  • Amount Testing We Test For
    Potency

    Third Party

    We work with third party labs to test the amount of vitamins, minerals, and specific active ingredients.

Discover what our customers say about D-Mannose

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Resources

The science behind the claims

  • D-mannose powder for prophylaxis of recurrent urinary tract infections in women: A randomized clinical trial
    Kranjčec B, Papeš D, Altarac S.D-mannose powder for prophylaxis of recurrent urinary tract infections in women: A randomized clinical trial. World J Urol. 2014;32(1):79-84.
  • Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: A randomized controlled trial
    Mathison BD, Kimble LL, Kaspar KL, Khoo C, Chew BP. Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: A randomized controlled trial. Nutrition research (New York, N.Y.). 2014;34(5):420-427.
  • Adherence of escherichia coli to human mucosal cells mediated by mannose receptors
    SHARON N, OFEK I, MIRELMAN D. Adherence of escherichia coli to human mucosal cells mediated by mannose receptors. Nature. 1977;265(5595):623-625.
  • Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated escherichia coli to eucaryotic cells
    Zafriri D, Ofek I, Adar R, Pocino M, Sharon N.Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated escherichia coli to eucaryotic cells. Antimicrob Agents Chemother. 1989;33(1):92-98.
  • Enhancing health benefits of berries through phenolic antioxidant enrichment: Focus on cranberry
    Vattem DA, Ghaedian R, Shetty K. Enhancing health benefits of berries through phenolic antioxidant enrichment: Focus on cranberry. Asia Pac J Clin Nutr. 2005;14(2):120.
  • Preventing urinary tract infections after menopause without antibiotics
    Caretto M, Giannini A, Russo E, Simoncini T.Preventing urinary tract infections after menopause without antibiotics. Maturitas. 2017;99:43-46.
  • Cranberries and their bioactive constituents in human health
    Blumberg JB, Camesano TA, Cassidy A, et al. Cranberries and their bioactive constituents in human health. Advances in nutrition (Bethesda, Md.). 2013;4(6):618-632.
  • Impact of cranberries on gut microbiota and cardiometabolic health: Proceedings of the cranberry health research conference 2015
    Blumberg JB, Basu A, Krueger CG, et al.Impact of cranberries on gut microbiota and cardiometabolic health: Proceedings of the cranberry health research conference 2015. Advances in nutrition (Bethesda, Md.). 2016;7(4):770S.
  • Prebiotic properties of mannose and its effect on specific resistance
    Korneeva OS, Cheremushkina IV, Glushchenko AS, et al. Prebiotic properties of mannose and its effect on specific resistance. Zh Mikrobiol Epidemiol Immunobiol. 2012(5):67.
  • Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers
    Pedersen CB, Kyle J, Jenkinson AM, Gardner PT, McPhail DB, Duthie GG.Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers. Eur J Clin Nutr. 2000;54(5):405-408.